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Increase the dose in increments of rosiglitazone 4 mg and/or metformin 500 mg up to the max recommended total daily dose of 8 mg/2,000 mg. Because the risk of metformin accumulation and lactic acidosis increases with the degree of renal function impairment, assess renal function before starting therapy and at least annually thereafter. , x-rays, CT scans, and MRIs) that use intravenous contrast media—Use of metformin and rosiglitazone should be discontinued before you have one of these procedures. , Isordil®, Imdur®, or Sorbitrate®) before you start taking metformin and rosiglitazone. Use of metformin and rosiglitazone can increase the risk of serious side effects in these patients.

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